A new isoflavone from the roots of Ficus auriculata1

作者：Qi, Cui-Cui; Fu, Yan-Hui; Chen, Wen-Hao; Chen, Guang-Ying; Dai, Chun-Yan; Song, Xiao-Ping^*; Han, Chang-Ri^*

来源：Natural Product Research, 2018, 32(1): 43-47.

DOI：10.1080/14786419.2017.1329728

• Ficus auriculata
• isoflavone
• 5,7,4 '-trihydroxy-3 '-hydroxymethylisoflavone
• antibacterial activities

A new isoflavone, 5,7,4'-trihydroxy-3'-hydroxymethylisoflavone (1), together with three known isoflavones, 3'-formyl-5,4'-dihydroxy-7-methoxyisoflavone (2), ficuisoflavone (3) and alpinumisoflavone (4), were isolated from the roots of Ficus auriculata. Among them, 1 is a rare isoflavone containing 16 carbon atoms on the carbon skeleton. The structure of 1 was elucidated by extensive spectroscopic methods and the known compounds were identified by comparisons with data reported in the literature. All compounds were evaluated for their antibacterial activities against five terrestrial pathogenic bacteria in vitro. Compounds 1-4 showed significant antibacterial activities against various terrestrial pathogenic bacteria with MIC values ranging from 1.30 to 9.93 mu M. @@@ [GRAPHICS] @@@ .

• 出版日期2018
• 单位海南师范大学