Antioxidant lipoxygenase inhibitors from the leaf extracts of Simmondsia chinensis

作者：Abdel Mageed Wael Mostafa^*; Bayoumi Soad Abdel Latief Hassan; Salama Awwad Abdoh Radwan; Salem Bekhit Mounir Mohamed; Abd Alrahman Sherif Hussein; Sayed Hanaa Mohamed

来源：Asian Pacific Journal of Tropical Medicine, 2014, 7: S521-S526.

DOI：10.1016/S1995-7645(14)60284-4

• Simmondsia chinensis
• Jojoba
• Flavonoids
• Lignans
• Antioxidant
• Lipoxygenase inhibitors

Objective: To isolate and identify chemical constituents with antioxidant and lipoxygenase inhibitory effects of the ethanolic extract of Sinnnondsia chinensis (Jojoba) leaves. %26lt;br%26gt;Methods: The alcoholic extract was subjected to successive solvent fractionation. The antioxidant active fractions (chloroform, ethyl acetate and aqueous fractions) were subjected to a combination of different chromatographic techniques guided by the antioxidant assay with DPPH. The structures of the isolated compounds were elucidated on the basis of spectroscopic evidences and correlated with known compounds. The antioxidant activity was assessed quantitively using DPPH and beta-carotene methods. The inhibitory potential against enzyme lipoxygenase was assessed on soybean lipoxygenase enzyme. %26lt;br%26gt;Results: Ten flavonoids and four lignans were isolated. Flavonoid aglycones showed stronger antioxidant and lipoxygenase inhibitory effects than their glycosides. Lignoid glycosides showed moderate to weak antioxidant and lipoxygenase inhibitory effects. %26lt;br%26gt;Conclusions: A total of 14 compounds were isolated and identified from Simmondsia chinensis; 12 of them were isolated for the first time. This is the first report that highlights deeply on the phenolic content of jojoba and their potential biological activities and shows the importance of this plant as a good source of phenolics in particular the flavonoid content.

• 出版日期2014-9