Antimicrobial performance of nanostructured silica-titania sieves loaded with izohidrafural against microbial strains isolated from urinary tract infections

作者：Al Tameemi Mustafa Basim M; Stan Raluca^*; Prisacari Viorel; Voicu Georgeta; Popa Marcela; Chifiriuc Mariana Carmen; Ott Cristina; Marton George; Meghea Aurelia

来源：Comptes Rendus Chimie, 2017, 20(5): 475-483.

DOI：10.1016/j.crci.2016.09.007

• Silica-titania sieves
• Antimicrobial activity
• Izohidrafural
• Urinary tract infections
• Synergistic effect

This study aimed to examine the efficiency of novel bioactive nanostructures represented by silica-titania sieves used as carriers for a new antibacterial agent izohidrafural against bacterial strains isolated from nosocomial urinary tract infections, by using biological quantitative assays. Several release trials have been established and compared with MCM-41 in parallel experiments to achieve the optimum release profile. The obtained systems showed that silica-titania sieves loaded with izohidrafural proved to be the most active material against Klebsiella pneumoniae (average minimal inhibitory concentration [MIC] 40.62 mu g/mL), desaminase-positive strains (average MIC 2.925 mu g/mL), and Proteus mirabilis (average MIC 9.37 mu g/mL), the last being reported with the highest growth rate in the urinary tract catheters. In contrast, the nonloaded silica titanium sieves exhibited the highest antimicrobial activity against the Gram-positive cocci. Izohidrafural exhibited the highest antimicrobial efficiency, superior to the common drug nitrofurantoin against most Escherichia coli strains, with average MIC of 4.68 mu g/mL.

• 出版日期2017-5