Modafinil treatment prevents REM sleep deprivation-induced brain function impairment by increasing MMP-9 expression

作者：He, Bin; Peng, Hua; Zhao, Ying; Zhou, Hui; Zhao, Zhongxin^*

来源：Brain Research, 2011, 1426: 38-42.

DOI：10.1016/j.brainres.2011.09.002

• Modafinil
• MMP-9
• Cognitive function
• Synaptic plasticity

Previous work showed that sleep deprivation (SD) impairs hippocampal-dependent cognitive function and synaptic plasticity, and a novel wake-promoting agent modafinil prevents SD-induced memory impairment in rat. However, the mechanisms by which modafinil prevented REM-SD-induced impairment of brain function remain poorly understood. In the present study, rats were sleep-deprived by using the modified multiple platform method and brain function was detected. The results showed that modafinil treatment prevented REM-SD-induced impairment of cognitive function. Modafinil significantly reduced the number of errors compared to placebo and upregulated synapsin I expression in the dorsal hippocampal CA3 region. A synaptic plasticity-related gene, MMP-9 expression was also upregulated in modafinil-treated rats. Importantly, downregulation of MMP-9 expression by special siRNA decreased synapsin I protein levels and synapse numbers. Therefore, we demonstrated that modafinil increased cognition function and synaptic plasticity, at least in part by increasing MMP-9 expression in REM-SD rats.

• 出版日期2011-12-2
• 单位天津市中医药研究院附属医院; 中国人民解放军第二军医大学