科研之友
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摘要
The human P2Y(11) nucleotide receptor plays key role in immune-responses in brain and other tissues. We provide evidence for significant functional disturbance of the P2Y(11) receptor carrying the Alanine-87-Threonine mutation caused by natural polymorphism. This receptor defect is apparent only when co-expressed with P2Y(1) receptors. We found reductions in ligand-induced calcium and cAMP responses and in nucleotide-induced receptor internalization / resensitization. Thus, prolonged nucleotide treatments are the basis for the molecular defects of the mutant receptor in diseases.
- 出版日期2014-5
