A facile synthesis of 4-methylene-1,3-oxazolidines from gamma-hydroxybutynoate and N-tosylimines

作者：Fleury Bregeot Nicolas; Voituriez Arnaud; Retailleau Pascal; Marinetti Angela^*

来源：Tetrahedron Letters, 2009, 50(33): 4700-4702.

DOI：10.1016/j.tetlet.2009.06.009

• Organocatalysis
• Phosphine catalyzed
• Activated propargylic alcohol
• Methyleneoxazolidine

Both nucleophilic and basic catalysts have been used to promote the cyclization reactions between gamma-hydroxybutynoate and N-tosylimines to afford 4-methylene-1,3-oxazolidines in good yields. E- and Z-isomers of the final products have been isolated and characterized by NMR spectroscopy and X-ray data.

• 出版日期2009-8-19