Flavonoid glycosides from Microtea debilis and their cytotoxic and anti-inflammatory effects

作者：Bai Naisheng; He Kan^*; Roller Marc; Lai Ching Shu; Shao Xi; Pan Min Hsiung; Bily Antoine; Ho Chi Tang

来源：Fitoterapia, 2011, 82(2): 168-172.

DOI：10.1016/j.fitote.2010.08.014

• Microtea debilis
• 5-O-beta-D-Glucopyranosyl cirsimaritin
• 5, 4 '-O-beta-D-Diglucopyranosyl cirsimaritin
• Human cancer cell lines (Hen G2, COLO 205, HL-60)
• Anti-inflammatory

Two new 5-O-glucosylflavones, 5-O-beta-D-glucopyranosyl cirsimaritin (1) and 5, 4'-O-beta-D-diglucopyranosyl cirsimaritin (2), four known flavonoids, cirsimarin (3), cirsimaritin (4), salvigenin (5), 4', 5-dihydroxy-7-methoxyflavone (6), and a norisoprenoid, vomifoliol (7), have been isolated from the aerial parts of Microtea debilis. All isolates were tested for cytotoxicity in human cancer cell lines (Hep G2, COLO 205, and HL-60) and anti-inflammatory activities in LPS-treated RAW264.7 macrophages. Compound 6 was found to be a potent inhibitor to nitrite production in macrophages. Compounds 2, 4, 6, and 7 showed moderate anti-proliferative activity against COLO-205 cells with IC(50) values of 7.1, 13.1, 6.1, and 6.8 mu M, respectively.

• 出版日期2011-3