Tumour necrosis factor-alpha gene polymorphisms and susceptibility to oral lichen planus

作者：Kimkong I; Hirankarn N; Nakkuntod J; Kitkumthorn N^*

来源：Oral Diseases, 2011, 17(2): 206-209.

DOI：10.1111/j.1601-0825.2010.01722.x

• oral lichen planus
• polymorphisms
• tumour necrosis factor-alpha

OBJECTIVE: This study is aimed to investigate the association between OLP susceptibility and clinical type in the Thai population and three polymorphisms within the promoter region of the TNF-alpha at positions -863, -308 and -238 which have putative functional significances.
MATERIALS AND METHODS: Genomic DNA from 75 Thai patients with OLP and 154 healthy controls were genotyped for TNF-alpha polymorphisms - -863(rs1800630), -308(rs1800629), and -238(rs361525) - using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
RESULTS: We found a higher proportion of TNF-alpha-308 AA genotype (high producer genotype) among OLP patients (5/75; 6.67%) when compared to healthy controls (1/154; 0.65%; OR = 10.93; 95% CI = 1.21-251.9). For other polymorphisms (-863 and -238), we did not find any significant association with OLP development; this was also the case with haplotype analysis (-863/-308/-238).
CONCLUSION: TNF-alpha-308AA may play a relevant role in the susceptibility and severity of OLP in the Thai population. However, further investigation of this study is needed. Oral Diseases (2011) 17, 206-209

• 出版日期2011-3