Accelerated Step-Up Infliximab Use Is Associated with Sustained Primary Response in Pediatric Crohn's Disease

作者：Ling, J.; Buurman, D.; Ravikumara, M.; Mews, C.; Thacker, K.; Grover, Z.^*

来源：Digestive Diseases and Sciences, 2018, 63(4): 1003-1010.

DOI：10.1007/s10620-018-4969-8

• Infliximab
• Sustained primary response
• Loss of response
• Accelerated early use of Infliximab

Earlier introduction of infliximab (IFX) in Crohn's disease (CD) may be associated with a sustained remission.
Children on scheduled IFX therapy for predominant luminal CD after successful induction (drop in PCDAI by >= 15) and a minimum of 2-year IFX follow-up were included. We compared outcomes of children treated with early (within 3 months from diagnosis) versus later IFX (after failing conventional therapy >= 3 months) and identify clinical predictors of sustained primary response (SPR) in our cohort. SPR was defined as CS-free clinical remission without requiring IFX dose escalation and/or surgical excision and/or switch to second anti-TNFs due to LOR or allergic reaction.
Sixty-four children received IFX therapy for CD during the study period. Forty-three children on scheduled IFX therapy for luminal CD met the inclusion criteria. During the median follow-up of 3.05 years (IQR 2.6-3.5 years), SPR was observed in 17/43 (40%). SPR was associated with shorter time from diagnosis to the initiation of IFX (5.4 vs. 18.7 months, p = 0.006). Binary logistic regression using multiple variables also confirmed that only early use of IFX is associated with SPR.
Early step-up use of IFX in children with CD with inadequate clinical response to conventional therapies leads to sustained primary response over 2 years.

• 出版日期2018-4