Adaptation of Innate Lymphoid Cells to a Micronutrient Deficiency Promotes Type 2 Barrier Immunity

作者:Spencer, S. P.; Wilhelm, C.; Yang, Q.; Hall, J. A.; Bouladoux, N.; Boyd, A.; Nutman, T. B.; Urban, J. F., Jr.; Wang, J.; Ramalingam, T. R.; Bhandoola, A.; Wynn, T. A.; Belkaid, Y.*
来源:Science, 2014, 343(6169): 432-437.
DOI:10.1126/science.1247606

摘要

How the immune system adapts to malnutrition to sustain immunity at barrier surfaces, such as the intestine, remains unclear. Vitamin A deficiency is one of the most common micronutrient deficiencies and is associated with profound defects in adaptive immunity. Here, we found that type 3 innate lymphoid cells (ILC3s) are severely diminished in vitamin A-deficient settings, which results in compromised immunity to acute bacterial infection. However, vitamin A deprivation paradoxically resulted in dramatic expansion of interleukin-13 (IL-13)-producing ILC2s and resistance to nematode infection in mice, which revealed that ILCs are primary sensors of dietary stress. Further, these data indicate that, during malnutrition, a switch to innate type 2 immunity may represent a powerful adaptation of the immune system to promote host survival in the face of ongoing barrier challenges.

  • 出版日期2014-1-24

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