An efficient one-pot three-component synthesis of pyrimido[4,5-d]pyrimidine derivatives in aqueous medium

作者：Badvel Sreedhar; Gopireddy Raveendra Reddy; Shaik Thaslim Basha; Hasti Sudhamani; Tummaluru Veera Reddy^*; Chamarthi Naga Raju

来源：Chemistry of Heterocyclic Compounds, 2015, 51(8): 749-753.

DOI：10.1007/s10593-015-1769-3

• 6-amino-N,N-dimethyluracil
• phenylisocyanate
• phenylisothiocyanate
• Lewis acid
• PEG-bound sulfonic acid
• three-component reaction

A fast, efficient, and green synthesis of pyrimido[4,5-d]pyrimidine derivatives has been achieved via one-pot three-component reaction starting from 6-amino-N,N-dimethyluracil, phenylisothiocyanate or phenylisocyanate, and aromatic aldehydes in the presence of polyethylene glycol-bound sulfonic acid as a catalyst in water as solvent.

• 出版日期2015-8