Advancing rapid point-of-care viral diagnostics to a clinical setting

作者：Weidemaier Kristin; Carrino John; Curry Adam; Connor John H; Liebmann Vinson Andrea^*

来源：Future Virology, 2015, 10(3): 313-328.

DOI：10.2217/FVL.14.117

• developing countries
• differential fever diagnosis
• HPV
• immunoassay
• PCR
• POC
• POC diagnosis
• respiratory diseases
• viral diagnosis

We discuss here critical factors in ensuring the success of a viral diagnostic at the point of care. Molecular and immunoassay approaches are reviewed with a focus on their ability to meet the infrastructure and workflow limitations in clinical settings in both the developed and developing world. In addition to being low cost, easy-to-use, accurate and adapted for the intended laboratory and healthcare environment, viral diagnostics must also provide information that appropriately directs clinical treatment decisions. We discuss the challenges and implications of linking diagnostics to clinical decision-making at the point of care using three examples: respiratory viruses in the developed world, differential fever diagnosis in the developing world and HPV detection in resource-limited settings.

• 出版日期2015