科研之友
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摘要
A new streptomyces strain designated L0804, producing antimicrobial substances, was isolated from marine mud in Qiangang, Jiangsu province, China. On the basis of cellular morphology, physiological and chemo-taxonomic characterization and phylogenetic similarity of 16S rDNA gene sequences, the strain L0804 was identified as Streptomyces roseogilvus var. marine. However, the phylogenetic analysis indicated that strain L0804 represents a distinct phyletic line suggesting a new genomic species. Two antimicrobial compounds were isolated and purified from the strain L0804 culture broth using various separation procedures. The two active compounds were elucidated by HPLC, UV-VIS, IR and NMR spectroscopy. One was a mixture of at least three compounds belonging to alkaloids homologue, the other was griseoviridin. The antimicrobial activity and cytotoxicity of the two active compounds were compared. The results showed that strain L0804 was a new potential marine microorganism producing griseoviridin. Simultaneously, strain L0804 can also produce valuable substance of alkaloids homologue.
