Additive Effects of Intermittent Hypobaric Hypoxia and Endurance Training on Bodyweight, Food Intake, and Oxygen Consumption in Rats

作者：Cabrera Aguilera Ignacio; Rizo Roca David; Marques Elisa A; Santocildes Garoa; Pages Teresa; Viscor Gines; Ascensao Antonio A; Magalhaes Jose; Torrella Joan Ramon^*

来源：High Altitude Medicine & Biology, 2018, 19(3): 278-285.

DOI：10.1089/ham.2018.0013

• endurance exercise training
• intermittent hypobaric hypoxia
• oxygen consumption
• weight loss

Cabrera-Aguilera, Ignacio, David Rizo-Roca, Elisa A. Marques, Garoa Santocildes, Teresa Pages, Gines Viscor, Antonio A. AscensAo, Jose MagalhAes, and Joan Ramon Torrella. Additive effects of intermittent hypobaric hypoxia and endurance training on bodyweight, food intake, and oxygen consumption in rats. High Alt Med Biol 00:000-000, 2018.We used an animal model to elucidate the effects of an intermittent hypobaric hypoxia (IHH) and endurance exercise training (EET) protocol on bodyweight (BW), food and water intake, and oxygen consumption. Twenty-eight young adult male rats were divided into four groups: normoxic sedentary (NS), normoxic exercised (NE), hypoxic sedentary (HS), and hypoxic exercised (HE). Normoxic groups were maintained at an atmospheric pressure equivalent to sea level, whereas the IHH protocol consisted of 5 hours per day for 33 days at a simulated altitude of 6000m. Exercised groups ran in normobaric conditions on a treadmill for 1 hour/day for 5 weeks at a speed of 25m/min. At the end of the protocol, both hypoxic groups showed significant decreases in BW from the ninth day of exposure, reaching final 10% (HS) to 14.5% (HE) differences when compared with NS. NE rats also showed a significant weight reduction after the 19th day, with a decrease of 7.4%. The BW of hypoxic animals was related to significant hypophagia elicited by IHH exposure (from 8% to 12%). In contrast, EET had no effect on food ingestion. Total water intake was not affected by hypoxia but was significantly increased by exercise. An analysis of oxygen consumption at rest (mL O-2/[kgmin]) revealed two findings: a significant decrease in both hypoxic groups after the protocol (HS, 21.7 +/- 0.70 vs. 19.1 +/- 0.78 and HE, 22.8 +/- 0.80 vs. 17.1 +/- 0.90) and a significant difference at the end of the protocol between NE (21.3 +/- 0.77) and HE (17.1 +/- 0.90). These results demonstrate that IHH and EET had an additive effect on BW loss, providing evidence that rats underwent a metabolic adaptation through a reduction in oxygen consumption measured under normoxic conditions. These data suggest that the combination of IHH and EET could serve as an alternative treatment for the management of overweight and obesity.

• 出版日期2018-9