Analysis of the Pathogenic Factors and Management of Dry Eye in Ocular Surface Disorders

作者：Nebbioso Marcella^*; Del Regno Paola; Gharbiya Magda; Sacchetti Marta; Plateroti Rocco; Lambiase Alessandro

来源：International Journal of Molecular Sciences, 2017, 18(8): 1764.

DOI：10.3390/ijms18081764

• dry eye
• lacrimal gland
• lipids and lipidomics
• Meibomian gland
• ocular surface disorders
• proteins and proteomics
• tear film

The tear film represents the interface between the eye and the environment. The alteration of the delicate balance that regulates the secretion and distribution of the tear film determines the dry eye (DE) syndrome. Despite having a multifactorial origin, the main risk factors are female gender and advanced age. Likewise, morphological changes in several glands and in the chemical composition of their secretions, such as proteins, mucins, lipidics, aqueous tears, and salinity, are highly relevant factors that maintain a steady ocular surface. Another key factor of recurrence and onset of the disease is the presence of local and/or systemic inflammation that involves the ocular surface. DE syndrome is one of the most commonly encountered diseases in clinical practice, and many other causes related to daily life and the increase in average life expectancy will contribute to its onset. This review will consider the disorders of the ocular surface that give rise to such a widespread pathology. At the end, the most recent therapeutic options for the management of DE will be briefly discussed according to the specific underlying pathology.

• 出版日期2017-8