Acute-phase response following full-mouth versus quadrant non-surgical periodontal treatment: A randomized clinical trial

作者：Graziani Filippo^*; Cei Silvia; Orlandi Marco; Gennai Stefano; Gabriele Mario; Filice Natalia; Nisi Marco; D'Aiuto Francesco

来源：Journal of Clinical Periodontology, 2015, 42(9): 843-852.

DOI：10.1111/jcpe.12451

• C-reactive protein
• full mouth
• interleukin-6
• quadrant
• scaling and root planing

AimA moderate acute-phase response occurs 24-h following full-mouth non-surgical treatment (FM-SRP). The aim of this study was to compare acute-phase (24-h) and medium-term (3months) inflammation after quadrant scaling (Q-SRP) versus FM-SRP.
Material & MethodsThirty-eight periodontitis-affected subjects were randomly allocated to FM-SRP or Q-SRP after a baseline visit. Periodontal and anthropometric parameters were collected at baseline and 3months. Serum samples were drawn at baseline, 1, 7, and 90days after treatment. High-sensitivity assays of inflammation and endothelial assays were performed.
ResultsFM-SRP produced a greater acute-phase response after 24h [threefold increase in C-reactive protein (CRP), twofold increase in interleukin (IL-6), and a slight increase in tumour necrosis factor]. No differences in systemic biomarkers were noted between groups at any later follow-ups. Both periodontal treatments produced a comparable improvement in clinical periodontal parameters with no between-group differences. Treatment time was positively associated with the relative 24-h increase in CRP (R=0.5, p<0.001) and IL-6 (R=0.5, p=0.002), while the number of deeper (>6mm) pockets predicted only the relative increase in IL-6 (R=0.4, p<0.05).
ConclusionsFM-SRP triggers a moderate acute-phase response of 24h duration compared to Q-SRP. Further research is needed to assess the eventual impact of such findings on the risk of vascular events is advocated. (ClinicalTrials.gov NCT01857804).

• 出版日期2015-9