A convenient [hydroxy(tosyloxy)iodo]benzene-mediated one-pot synthesis of 2-arylimidazo[2,1-b]benzothiazoles

作者：Sumran Garima^*; Aggarwal Ranjana

来源：Journal of Sulfur Chemistry, 2015, 36(2): 170-177.

DOI：10.1080/17415993.2014.996221

• imidazo[2,1-b]benzothiazoles
• [hydroxy(tosyloxy)iodo]benzene
• hypervalent iodine
• 2-amino-6-(substituted)benzothiazoles
• alpha-tosyloxyketones

Several 2-arylimidazo[2,1-b]benzothiazoles (4) have been conveniently synthesized in one-pot reactions via alpha-tosyloxylation of enolizable ketones (1) using [hydroxy(tosyloxy)iodo]benzene 2 in acetonitrile, followed by treatment with 2-amino-6-(substituted)benzothiazoles (3). The present protocol offers several advantages towards general access of 2-arylimidazo[2,1-b]benzothiazoles, including an intriguing alternative to the literature protocols, a readily available nontoxic reagent, operational simplicity and an environmentally benign procedure.

• 出版日期2015-3-4