MULTICOMPONENT SYNTHESIS OF 1,2,3-TRIAZOL-4-YL-METHYLTHIO-3-ARYLQUINAZOLIN-4(3H)-ONE DERIVATIVES

作者：Koohshari Majid; Dabiri Minoo^*; Salehi Peyman; Bahramnejad Mahboobeh

来源：Synthetic Communications, 2012, 42(16): 2415-2422.

DOI：10.1080/00397911.2011.558968

• Azide
• click chemistry
• propargyl bromide
• quinazolinone
• 1,2,3-triazole

A novel, one-pot, three-component reaction for the synthesis of novel 1,2,3-triazol-4-yl-methylthio-3-arylquinazolin-4(3H)-one derivatives using the Huisgen 1,3-dipolar cycloaddition reaction of organic azides and in situ-prepared terminal alkynes in good to excellent yields is reported.

• 出版日期2012