Analysis of pathogenicity and immune efficacy of fowl adenovirus serotype 4 isolates

作者：Ruan, S.; Zhao, J.; He, Z.; Yang, H.; Zhang, G.^*

来源：Poultry Science, 2018, 97(8): 2647-2653.

DOI：10.3382/ps/pey113

• fowl adenovirus serotype 4
• hepatitis-hydropericardium syndrome
• pathogenicity
• vaccine
• efficacy

In the present study, the pathogenicity of fowl adenovirus (FAdV) serotype 4 strain HB1501 was systematically determined by using different doses and routes of inoculation in chickens and assessed the immune efficacy induced by fowl adenovirus serotype 4 (FAdV-4) strain SB15 in a vaccination trial. The results revealed that strain HB1501 was highly virulent in chickens, inflicting 30 to 100% mortality when administered by intramuscular and intravenous routes, and its pathogenicity was influenced markedly by the inoculation route. The inactivated oil-emulsion FAdV-4 vaccine derived from strain SB15 completely protected specific pathogen-free chickens against morbidity and mortality following infection with the virulent FAdV-4 strain HB1501. Importantly, no obvious clinical signs or gross lesions were observed and high antibody levels against FAdV were measured in the SB15-vaccinated chickens, indicating the potential of this strain to become an alternative vaccine candidate. This study provides detailed information on the pathogenicity of FAdV-4, which should be of great value to the control of hepatitis-hydropericardium syndrome.

• 出版日期2018-8
• 单位中国农业大学