Multidrug overdose-induced myoclonus complicated by rhabdomyolysis: possible role and mechanism of muscle toxicity of risperidone

作者：Hsu Y C; Yeh Y W^*

来源：Journal of Clinical Pharmacy and Therapeutics, 2014, 39(6): 698-700.

DOI：10.1111/jcpt.12205

• myoclonus
• overdose
• rhabdomyolysis
• risperidone
• schizophrenia

What is known and objectiveAtypical antipsychotics are considered safe for treating schizophrenia and are rarely reported to induce rhabdomyolysis.
Case summaryHere is a case of a woman with schizophrenia who developed rhabdomyolysis following overdose of risperidone, trihexyphenidyl and benzodiazepines. There was no recurrence of rhabdomyolysis when above medication was resumed with therapeutic dose.
What is new and conclusionMultidrug overdose are common but are rarely reported to induce rhabdomyolysis. Overdose risperidone may increase the risk of rhabdomyolysis and need to be kept in mind.

• 出版日期2014-12