A Collision Tumor Consisting of Granular Cell Tumor and Adenocarcinoma in the Uterus of an Aged Djungarian Hamster

作者：Golbar Hossain M; Izawa Takeshi; Kuwamura Mitsuru; Okamura Kensaku; Fujita Daisuke; Tagami Yukari; Sasai Hiroshi; Yamate Jyoji^*

来源：Journal of Toxicologic Pathology, 2011, 24(4): 233-237.

DOI：10.1293/tox.24.233

• adenocarcinoma
• collision tumor
• granular cell
• hamster
• uterus

A neoplastic nodular lesion consisting of an admixture of granular cell tumor and adenocarcinoma was found in the uterus of a 26-month-old Djungarian hamster. Neoplastic cells of the uterine adenocarcinoma showed an epithelial nature in their growth patterns and by cytokeratin-immunopositive reaction, exhibiting nuclear pleomorphism. The granular cells had an abundant amount of fine granular eosinophilic cytoplasm and eccentric or central nuclei with no nuclear atypia; the granular structures were positive for periodic acid-Schiff with diastase resistance and were confirmed as lysosomes/autophagosomes by electron microscopy; immunohistochemically, the cells reacted to desmin, vimentin and a-smooth muscle actin and negatively for neurogenic, histiocyte/macrophage or epithelial markers, indicating smooth muscle origin. Because these tumors were generated from different cell origins, a diagnosis of collision tumor was made. (DOI: 10.1293/tox.24.233; J Toxicol Pathol 2011; 24: 233-237)

• 出版日期2011