An eIF4E-interacting peptide induces cell death in cancer cell lines

作者：Masse M; Glippa V; Saad H; Le Bloas R; Gauffeny I; Berthou C; Czjzek M; Cormier P; Cosson B^*

来源：Cell Death & Disease, 2014, 5(10): e1500.

DOI：10.1038/cddis.2014.457

The eukaryotic initiation factor eIF4E is essential for cap-dependent initiation of translation in eukaryotes. Abnormal regulation of eIF4E has been implicated in oncogenic transformation. We developed an eIF4E-binding peptide derived from Angel1, a partner of eIF4E that we recently identified. We show here that this peptide fused to a penetratin motif causes drastic and rapid cell death in several epithelial cancer cell lines. This necrotic cell death was characterized by a drop in ATP levels with F-actin network injury being a key step in extensive plasma membrane blebbing and membrane permeabilization. This synthetic eIF4E-binding peptide provides a candidate pharmacophore for a promising new cancer therapy strategy.

• 出版日期2014-10