Deciphering the Innate Lymphoid Cell Transcriptional Program

作者：Seillet Cyril; Mielke Lisa A; Amann Zalcenstein Daniela B; Su Shian; Gao Jerry; Almeida Francisca F; Shi Wei; Ritchie Matthew E; Naik Shalin H; Huntington Nicholas D; Carotta Sebastian; Belz Gabrielle T

来源：Cell Reports, 2016, 17(2): 436-447.

DOI：10.1016/j.celrep.2016.09.025

Innate lymphoid cells (ILCs) are enriched at mucosal surfaces, where they provide immune surveillance. All ILC subsets develop from a common progenitor that gives rise to pre-committed progenitors for each of the ILC lineages. Currently, the temporal control of gene expression that guides the emergence of these progenitors is poorly understood. We used global transcriptional mapping to analyze gene expression in different ILC progenitors. We identified PD-1 to be specifically expressed in PLZF(+) ILCp and revealed that the timing and order of expression of the transcription factors NFIL3, ID2, and TCF-1 was critical. Importantly, induction of ILC lineage commitment required only transient expression of NFIL3 prior to ID2 and TCF-1 expression. These findings highlight the importance of the temporal program that permits commitment of progenitors to the ILC lineage, and they expand our understanding of the core transcriptional program by identifying potential regulators of ILC development.

• 出版日期2016-10-4
• 单位河北医科大学