A highly efficient heterogeneous palladium-catalyzed carbonylative annulation of 2-aminobenzamides with aryl iodides leading to quinazolinones

作者：You, Shengyong; Huang, Bin; Yan, Tao; Cai, Mingzhong^*

来源：Journal of Organometallic Chemistry, 2018, 875: 35-45.

DOI：10.1016/j.jorganchem.2018.09.003

• Carbonylative annulation
• Palladium
• Quinazolinone
• 2-Aminobenzamide
• Heterogeneous catalysis

The first heterogeneous carbonylative annulation of 2-aminobenzamides with aryl iodides was achieved in N, N-dimethylformamide (DMF) at 120 degrees C under 10 bar of carbon monoxide by using an MCM-41-immobilized bidentate phosphine palladium(II) complex [MCM-41-2P-Pd(OAc)(2)] as catalyst and 1,8-diazabicycloundec-7-ene (DBU) as base, yielding a wide variety of quinazolinone derivatives in good to excellent yields. The new heterogeneous palladium catalyst can easily be prepared by a simple procedure from commercially readily available reagents, and recovered by filtration of the reaction solution, and recycled up to eight times without significant loss of activity.

• 出版日期2018-11-15
• 单位江西省科学院; 中国科学院长春应用化学研究所; 江西师范大学