Application of an immobilised amylose-based chiral stationary phase to the development of new monoamine oxidase B inhibitors

作者：Sanna Maria Luisa; Maccioni Elias; Vigo Sara; Faggi Cristina; Cirilli Roberto^*

来源：Talanta, 2010, 82(1): 426-431.

DOI：10.1016/j.talanta.2010.04.039

• Chiralpak IA
• Enantioselective HPLC
• Enantiomers
• MAO-inhibitors
• Absolute configuration
• Chiroptical properties

A direct HPLC enantioseparation of three new chiral oxadiazoline derivatives endowed with potential MAO-B inhibitory activity was accomplished on the immobilised Chiralpak IA chiral stationary phase. Multi-mg amounts of enantiomers with high enantiomeric purity (ee >= 98%) were rapidly collected using pure dichloromethane as eluent. The absolute configuration and chiroptical properties of the enantiomers isolated at semipreparative scale were exhaustively determined.

• 出版日期2010-6-30