A Randomized, Evaluator-Blinded, Split-Face Comparison Study of the Efficacy and Safety of a Novel Mannitol Containing Monophasic Hyaluronic Acid Dermal Filler for the Treatment of Moderate to Severe Nasolabial Folds

作者：Kim Byung Wook; Moon Ik Jun; Yun Woo Jin; Chung Bo Young; Kim Sang Duck; Lee Ga Young^*; Chang Sung Eun^*

来源：Annals of Dermatology, 2016, 28(3): 297-303.

DOI：10.5021/ad.2016.28.3.297

• Dermal filler
• Hyaluronic acid
• Mannitol
• Nasolabial fold

Background: Mannitol containing monophasic filler with higher crosslinking has not been well studied for moderate and severe nasolabial fold (NLF) correction. Objective: To compare the efficacy and safety of a novel mannitol containing hyaluronic acid (HA) filler (HA-G) with biphasic HA filler (HA-P) for moderate and severe NLF correction. Methods: Thirteen subjects with symmetric moderate to severe NLF received HA-G (in one NLF) and HA-P (in other NLF) and were evaluated for 24 weeks. Results: At both 12 and 24 weeks, the mean improvement in Genzyme 6-point grading scale from baseline was significantly greater in the side of face that was treated with HA-G than HA-P (1.96 +/- 0.91 vs. 1.54 +/- 0.73 at week 12; p=0.044, 1.88 +/- 0.78 vs. 1.3 +/- 0.79 at week 24; p=0.027, respectively). At 12 weeks, the mean Global Aesthetic Improvement Scale score was 2.92 +/- 0.93 for HA-G and 2.31 +/- 0.95 for HA-P (p=0.008). Both fillers were well tolerated. Conclusion: The HA filler HA-G provides better efficacy and similar local tolerability compared with HA-P in 6 months following treatment for moderate and severe NLF.

• 出版日期2016-6