Adjunctive pharmacologic therapy in percutaneous coronary intervention: Part I antiplatelet therapy

作者：Kim Soo Joong; Giugliano Robert P; Jang Ik Kyung^*

来源：Coronary Artery Disease, 2011, 22(2): 100-112.

DOI：10.1097/MCA.0b013e32833729e3

• angioplasty
• anticoagulant
• antiplatelet therapy
• antithrombotic therapy
• platelet
• thrombin

Ischemic heart disease is a major cause of morbidity and mortality throughout the world. Percutaneous coronary intervention (PCI) has rapidly evolved from balloon angioplasty to drug-eluting stents over the past 25 years and has become an important treatment option for coronary heart disease. During PCI, atherosclerotic plaque disruption and the endothelium denudation stimulate both platelet aggregation and the thrombus generation. Therefore, pharmacological adjuvant therapies to protect the procedure-related thrombotic complication during PCI are indispensable. In addition to aspirin, whose benefit has been clearly shown in ischemic heart disease, clopidogrel and prasugrel have shown to dramatically reduce the rate of thrombosis after stent placement. The introduction of glycoprotein IIb/IIIa inhibitors has further improved the results of PCI especially in high-risk patients. In addition, several new drugs with antiplatelet or with antithrombin activities are currently under development.

• 出版日期2011-3