Association of Interleukin-1 gene clusters polymorphisms with primary open-angle glaucoma: a meta-analysis

作者：Li, Junhua; Feng, Yifan; Sung, Mi Sun; Lee, Tae Hee; Park, Sang Woo^*

来源：BMC Ophthalmology, 2017, 17(1): 218.

DOI：10.1186/s12886-017-0616-y

• Interleukin-1
• Polymorphism
• Primary open-angle glaucoma
• Meta-analysis

Background: Previous studies have associated the Interleukin-1 (IL-1) gene clusters polymorphisms with the risk of primary open-angle glaucoma (POAG). However, the results were not consistent. Here, we performed a meta-analysis to evaluate the role of IL-1 gene clusters polymorphisms in POAG susceptibility.
Methods: PubMed, EMBASE and Cochrane Library (up to July 15, 2017) were searched by two independent investigators. All case-control studies investigating the association between single-nucleotide polymorphisms (SNPs) of IL-1 gene clusters and POAG risk were included. Odds ratios (ORs) with 95% confidence intervals (CIs) were calculated for quantifying the strength of association that has been involved in at least two studies.
Results: Five studies on IL-1 beta rs16944 (c. -511C > T) (1053 cases and 986 controls), 4 studies on IL-1 alpha rs1800587 (c. -889C > T) (822 cases and 714 controls), and 4 studies on IL-1 beta rs1143634 (c. + 3953C > T) (798 cases and 730 controls) were included. The results suggest that all three SNPs were not associated with POAG risk. Stratification analyses indicated that the rs1143634 has a suggestive associated with high tension glaucoma (HTG) under dominant (P = 0.03), heterozygote (P = 0.04) and allelic models (P = 0.02), however, the weak association was nullified after Bonferroni adjustments for multiple tests.
Conclusions: Based on current meta-analysis, we indicated that there is lack of association between the three SNPs of IL-1 and POAG. However, this conclusion should be interpreted with caution and further well designed studies with large sample-size are required to validate the conclusion as low statistical powers.

• 出版日期2017-11-28
• 单位复旦大学