Use of a self-expanding metallic stent to palliate esophageal neoplastic obstruction in a dog

作者：Hansen Katherine S^*; Weisse Chick; Berent Allyson C; Dunn Marilyn; Caceres Ana V; Todd Kim L; Diroff Jeremy S

来源：Journal of the American Veterinary Medical Association, 2012, 240(10): 1202-1207.

Case Description-An 11-year-old spayed female Collie was evaluated because of regurgitation, dysphagia, severe ptyalism, coughing, and weight loss of approximately 12 weeks' duration. Esophageal squamous cell carcinoma had been diagnosed prior to referral on the basis of results of radiographic and endoscopic examination and histologic evaluation of biopsy samples. A percutaneous endoscopically placed gastrostomy (PEG) tube had been inserted 2 weeks prior to referral, and the dog was being treated for infection at the gastrostomy site.
Clinical Findings-Physical examination findings included marked ptyalism, stertor, and inflammation and discharge at the gastrostomy site.
Treatment and Outcome-Surgical options were declined by the owner, and palliative treatment was chosen to alleviate clinical signs and facilitate PEG tube removal. With fluoroscopic guidance, a self-expanding metallic stent was placed in the esophageal lumen at the site of obstruction. Botulinum toxin A was injected into the mandibular salivary glands under ultrasonographic guidance as treatment for severe ptyalism. Following discharge, clinical improvement was reported until euthanasia for unrelated disease 12 weeks after stent placement. Necropsy revealed that the stent had not migrated and had remained patent with some tumor ingrowth but no evidence of stricture or obstruction.
Clinical Relevance-Esophageal stenting effectively treated obstruction and improved clinical signs and may be beneficial for palliative treatment in other animals with malignant esophageal tumors. Although the degree to which botulinum toxin A injection into salivary glands improved clinical signs could not be determined, it may potentially be useful as adjunctive treatment to reduce severe ptyalism. (J Am Vet Med Assoc 2012;240:1202-1207)

• 出版日期2012-5-15