Adiponectin gene variants and decreased adiponectin plasma levels are associated with the risk of myocardial infarction in young age

作者：Ambroziak Michal^*; Kolanowska Monika; Bartoszewicz Zbigniew; Budaj Andrzej

来源：Gene, 2018, 642: 498-504.

DOI：10.1016/j.gene.2017.11.064

• Adiponectin
• Adiponectin gene variants
• Myocardial infarction in young age
• Premature coronary artery disease

The aim of the study was to investigate the role of adiponectin and 5 variants of its gene in the risk of premature myocardial infarction (MI).
The studied group (MI < 50) consisted of 158 young patients (125 men) aged < 50 with MI. The control groups consisted of 155 healthy people (97 men), aged < 50 and 202 patients (130 men) aged 50 with MI (MI >= 50).
There were statistically significant differences between MI < 50 patients and healthy control group in the prevalence of rs17300539:G > A (AA genotype: 19.3% vs. 0%, p < 0.0001) and rs72563731:C > T variants (CC genotype: 81.5% vs. 15.9%, p < 0.0001) and between MI < 50 and MI >= 50 patients in variants: rs17300539:G > A (AA genotype: 19.3% vs. 0.5%, p < 0.0001), rs72563731:C > T (CC genotype: 82.1% vs. 60.8%, p < 0.0001), rs1501299:G > T (TT genotype: 6.8% vs. 14.9%, p = 0.019) and rs822387:T > C (genotype CC: 1.5% vs. 0%, p = 0.017). Multivariate analysis showed a significantly higher risk of MI in young CC carriers of rs72563731:C > T and in young AA carriers of rs17300539:G > A. Total and HMW adiponectin plasma levels have been significantly lower in MI < 50 patients in comparison to MI >= 50 patients (p = 0.001 and p = 0.001, respectively) and to healthy subjects (p = 0.009 and p = 0.01, respectively).
Our study indicates the possible role of adiponectin and its genetic variants in MI in young age.

• 出版日期2018-2-5