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摘要
Three new pregnane alkaloids, named terminamines H-J (1-3), together with two known alkaloids (4 and 5), were isolated from the ethanol extract of Pachysandra terminalis. The structures of isolated compounds were elucidated by spectroscopic methods, including H-1 and C-13 NMR, 2D NMR, and HR-ESI-MS. Compounds 1, 4, and 5 revealed significant anti-metastasis activities. In addition, compound 1 inhibited the expression of p-PKC zeta in MDA-MB-231 cells, and compound 4 inhibited the expressions of p-PKC zeta in MDA-MB-231 and A549 cells.
- 出版日期2014-5-4
- 单位天津医科大学
