摘要
Two new and large molecular rectangles 4 and 5 were synthesized from two different arene-ruthenium [Ru-2(mu-eta(4)-C2O4)(MeOH)(2)(eta(6)-p-(PrC6H4Me)-C-i)(2)][O3SCF3](2) (2) and [Ru-2(p-cymene)(2)(donq)(OH2)(2)][O3SCF3](2) (donq = 5,8-dioxydo-1,4-naphthaquinonato) (3) acceptors and a new unsymmetrical N-(4-(pyridin-4-ylethynyl)phenyl) isonicotinamide (1) donor ligand. Xray crystallography of 4 confirmed a molecular rectangle. The H-1 NMR spectra of both rectangles 4 and 5 showed a mixture of two structural, head-to-tail (HTT) and head-to-head (HTH), type isomers in a 1:1 ratio. The cytotoxicities, of both rectangles have been established against Colo320 (colorectal cancer), A549 (lung cancer), MCF-7 (breast cancer), and H1299 (lung cancer) human cancer,cell lines. The cytotoxicity of rectangle 5 was found to be considerably stronger against all cancer cell lines than that of the reference drug cisplatin.
- 出版日期2012-5-14