An eco-friendly and water mediated product selective synthesis of 2-aminopyrimidines and their in vitro anti-bacterial evaluation

作者：Nagarajan Sangaraiah; Shanmugavelan Poovan; Sathishkumar Murugan; Selvi Ramasamy; Ponnuswamy Alagusundaram^*; Harikrishnan Hariharan; Shanmugaiah Vel****my; Murugavel Saminathan

来源：Bioorganic & Medicinal Chemistry Letters, 2014, 24(21): 4999-5007.

DOI：10.1016/j.bmcl.2014.09.027

• Water mediated
• Eco-friendly
• Product selective
• 2-Aminopyrimidines
• Anti-bacterial

A greener water mediated protocol for the efficient synthesis of a library of 2-amino-6-styryl pyrimidines (4) and their dihydro analogues (3) has been reported. Most of the saturated compounds (3) rather than their unsaturated analogues (4) showed better anti-bacterial (in vitro) activity against three human pathogens viz. Staphylococcus aureus, Klebsiella pneumonia and Escherichia coli. In particular, three of them (3b, 3i & 3k) exhibited high inhibition against the growth of all the three pathogens comparable with that of the reference drug, tetracycline.

• 出版日期2014-11-1