A Case of Nonfatal Intoxication Associated with the Recreational use of Diphenidine

作者：Gerace Enrico; Bovetto Elena; Di Corcia Daniele; Vincenti Marco; Salomone Alberto

来源：Journal of Forensic Sciences, 2017, 62(4): 1107-1111.

DOI：10.1111/1556-4029.13355

• forensic science
• diphenidine
• dissociative drugs
• new psychoactive substances
• intoxication
• designer drugs

Diphenidine is a dissociative drug that shows several psychotropic effects including euphoria, shifts in perception of reality, hallucinations, and transient anterograde amnesia. In this study, a case of acute intoxication occurring after diphenidine intake is reported. A 30-year-old Caucasian male was hospitalized after he was found in a confused and agitated state and unable to communicate. The physical examination displayed tachycardia, miotic pupils, and increased both body temperature and respiratory rate. After a liquid-liquid extraction procedure, GC/MS analysis revealed the presence of diphenidine in plasma and urine at concentrations of 308 and 631 ng/mL, respectively. Methylphenidate and diclazepam were also detected in the plasma. The clinical progress of the patient was favorable, and his symptoms were cured with a symptomatic treatment. The combined circumstantial elements and toxicological results of the case reported revealed the occurrence of an acute intoxication ascribable to the recreational abuse of diphenidine.

• 出版日期2017-7