Ace I/D polymorphism is associated with habitual physical activity in pubertal boys

作者：Maeestu Jarek; Laett Evelin; Raeaesk Triin; Sak Katrin; Laas Kariina; Juerimaee Jaak; Juerimaee Toivo

来源：Journal of Physiological Sciences, 2013, 63(6): 427-434.

DOI：10.1007/s12576-013-0280-9

• Physical activity
• Sedentary behaviour
• ACE gene
• Pubertal boys

We investigated the association between the angiotensin I-converting enzyme (ACE) gene insertion (I)/deletion (D) polymorphism and physical activity levels in boys at early pubertal stage (calendar age 12.04 +/- A 0.77 years). Body composition by DXA, pubertal stage and cardiovascular fitness on cycle ergometer were measured in addition to 7-day accelerometry. DNA was separated from the whole blood. Sedentary behaviour level was significantly lower in DD subjects compared to I allele carriers. A significant main effect of the D allele was found on total physical activity (F (1,256) = 5,453; p = 0.020; eta (2) = 0.021] and on light physical activity (F (1,256) = 4.74; p = 0.030; eta (2) = 0.018). Adding screen time as a covariate did not change ACE I/D polymorphism effect on total physical activity levels (F (2,256) = 3,326; p = 0.041; eta (2) = 0.025). Carriers of the D allele had significantly higher light physical activity (F (1,256) = 4,710; p = 0.031; eta (2) = 0.20), with screen time as covariate. In conclusion, ACE gene has a significant effect on sedentary, light and total physical activity levels in healthy 12-year-old boys.

• 出版日期2013-11