A facile and efficient method for synthesis of macrocyclic lipoglycopeptide

作者：Zhao Qingjie; Li Xiang; Li Wenjuan; Zou Yan; Hu Honggang^*; Wu Qiuye

来源：Tetrahedron, 2015, 71(7): 1018-1022.

DOI：10.1016/j.tet.2014.12.097

• Tyrocidine A
• Lipoglycopeptide
• Solid-phase peptide synthesis
• Macrocyclic peptide
• Glycosylation

An efficient and practical method for macrocyclic lipoglycopeptide synthesis was developed and utilized to synthesize lipoglycosylated derivatives of Tyrocidine A. The method is based on solid-phase peptide synthesis using 2-chlorotrityl resin as the solid-phase support and lipoglycosyl amino acids as building blocks. This synthetic method should be generally applicable to various macrocyclic lipoglycopeptides.

• 出版日期2015-2-18
• 单位中国人民解放军第二军医大学