Differential expression of the immunosuppressive enzyme IL4I1 in human induced Aiolos(+), but not natural Helios(+), FOXP3(+) Treg cells

作者：Scarlata Clara Maria; Celse Clotilde; Pignon Pascale; Ayyoub Maha^*; Valmori Danila

来源：European Journal of Immunology, 2015, 45(2): 474-479.

DOI：10.1002/eji.201444897

• FOXP3(+) Treg
• Immune regulation
• Immunosuppressive enzymes
• IL4I1
• T(H)17

IL4I1 encodes an L-phenylalanine oxidase that inhibits T-cell proliferation. It has been recently reported that IL4I1 is expressed in T(H)17 cells as part of a mechanism that limits their pathogenicity. We have previously identified a population of human FOXP3(+) Treg cells that secrete IL-17 ex vivo; here, we addressed the expression of IL4I1 in that Treg-cell population. We found that in ex vivo isolated circulating Treg cells, IL4I1 expression is induced by activation. Moreover, IL4I1 expression is restricted to cells that do not express Helios, a transcription factor that characterizes natural Treg cells, but that express Aiolos, which is involved in the differentiation of T(H)17 and induced Treg cells. We also showed that conversion of Treg cells under inflammatory conditions increases IL4I1 expression, likely as part of a regulatory loop that attempts to limit the pathogenicity resulting from their conversion into T(H)17. The specific expression of IL4I1 in T(H)17 and iTreg cells may provide insights into approaches that aim at modulating these populations in different pathological conditions involving inflammation-mediated immunosuppression.

• 出版日期2015-2