Association of Human Leukocyte Antigen Class I Polymorphism with Spontaneous Clearance of Hepatitis B Surface Antigen in Qidong Han Population

作者：Miao Fengqin; Sun Hang; Pan Ning; Xu Jinhuan; Qiu Jie; Shen Yuqing; Xie Wei; Zhang Jianqiong^*

来源：Clinical and Developmental Immunology, 2013, 2013: 145725.

DOI：10.1155/2013/145725

Aim. To investigate whether HLA class I polymorphisms could influence the clearance of hepatitis B surface antigen (HBsAg) in Qidong Han population. Methods. We genotyped HLA-A, -B, and -C loci of 448 individuals with HBV persistent infection and 140 persons with spontaneous clearance of HBsAg by polymerase chain reaction with sequencing based typing (PCR/SBT). All the individuals were unrelated males enrolled from Qidong Han population and were followed up for 10 years. Results. The frequency of HLA-A * 33:03:01G was increased in persistent HBV infection group (P value is 0.028), while frequency of HLA-B * 13: 01: 01G was increased in HBsAg clearance group (P value is 0.0004). Conclusion. These findings suggested that the host HLA class I polymorphism is an important factor in determining the outcomes of HBV infection.

• 出版日期2013
• 单位东南大学