Analysing the composition of outpatient antibiotic use: a tutorial on compositional data analysis

作者：Faes Christel^*; Molenberghs Geert; Hens Niel; Muller Arno; Goossens Herman; Coenen Samuel

来源：Journal of Antimicrobial Chemotherapy, 2011, 66(suppl_6): 89-94.

DOI：10.1093/jac/dkr461

• log-ratio analysis
• multivariate data
• staying-in-the-simplex analysis
• ambulatory care
• Europe

In this tutorial, statistical methods for studying outpatient use of antibiotics in Europe are described, using data provided by IMS Health. The methods are applied to two related research questions, namely the assessment of changes in the relative volume of use of different antibiotic subclasses over time and changes in the absolute volume of antibiotic use.

• 出版日期2011-12