ASSESSMENT OF LIPID PROFILES AND BONE MINERAL DENSITY IN RENAL TRANSPLANT PATIENTS

作者：Fernandez Castillo Rafael; Fernandez Gallegos Ruth; Pena Amaro Maria Pilar; Esteban de la Rosa Rafael Jose

来源：Nutricion Hospitalaria, 2015, 31(6): 2503-2510.

DOI：10.3305/nh.2015.31.6.8719

• Renal transplantation
• Lipid disorders
• Hyperlipidemia
• Hypertriglyceridemia
• Anthropometry
• Bone Mineral Density

Introduction: alterations in lipid metabolism and bone mineral metabolism disturbances are common disorders among renal transplant patients, contributing to the apparition of oxidative metabolic and cardiovascular diseases that threaten the integrity of the graft.
Aims: describe and observe the evolution of alterations in bone mineral density (BMD) and lipid abnormalities in a population of kidney transplant patients.
Material and method: the samples consisted of 119 kidney transplant patients of both sexes, measurements were performed pretransplant and posttransplant for five years of biochemical parameters, anthropometric measurements and measurement of bone mineral density at the lumbar spine, femur and radioulnar.
Results: during the five years after transplantation a significant increase in biochemical parameters, BMI, dyslipidemia, diabetes and hypertension occurs. At six months there is a high percentage of patients with pathologic BMD increase by 4.1% per year of transplantation.
Conclusions: after kidney transplantation, a large increase of hyperlipidemia associated with a characteristic pattern of altered lipid with elevated total cholesterol, low density lipoprotein, high density lipoprotein, and the resulting increase in triglycerides, occurs despite statin therapy, leading to an increase in risk factors for diabetes, hypertension, diseases and cardiovascualres further loss of bone mass which carries a high risk of serious fractures occurs, threatening kidney graft and quality of life of patients.

• 出版日期2015-6