Vitamin D in cutaneous carcinogenesis Part I

作者：Tang Jean Y^*; Fu Teresa; Lau Christopher; Oh Dennis H; Bikle Daniel D; Asgari Maryam M

来源：Journal of the American Academy of Dermatology, 2012, 67(5): 803.e1.

DOI：10.1016/j.jaad.2012.05.044

• 25(OH)D levels
• cholecalciferol
• supplements
• vitamin D
• ultraviolet radiation

Skin cancer is the most common cancer in the United States. Exposure to ultraviolet radiation is a known risk factor for skin cancer but is also the principal means by which the body obtains vitamin D. Several studies have suggested that vitamin D plays a protective role in a variety of internal malignancies. With regard to skin cancer, epidemiologic and laboratory studies suggest that vitamin D and its metabolites may have a similar protective effect. These noncalcemic actions of vitamin D have called into question whether the current recommended intake of vitamin D is too low for optimal health and cancer prevention. Part I will review the role of vitamin D in the epidermis; part II will review the role of vitamin D in keratinocyte-derived tumors to help frame the discussion on the possible role of vitamin D in the prevention of skin cancer. (J Am Acad Dermatol 2012;67:803.e1-12.)

• 出版日期2012-11