Acetoxybenzoylglycylglycines as Potential Cerebroprotective Compounds

作者：Brel' A K^*; Tyurenkov I N; Lisina S V; Popov S S; Verkholyak D V; Budaeva Yu N; Volotova E V; Atapina N V; Kurkin D V

来源：Pharmaceutical Chemistry Journal, 2018, 52(1): 37-41.

DOI：10.1007/s11094-018-1762-0

• carbonic acid amides
• hydroxybenzoic acid derivatives
• cerebroprotective agents
• synthesis

3,4,5-Trimethoxy- and 2-, 3-, and 4-acetoxybenzoylglycylglycines and their water-soluble potassium and lithium salts were synthesized. The cerebroprotective properties of the water-soluble potassium and lithium salts of acetoxybenzoylglycylglycines were studied experimentally. The most marked cerebroprotective proteins in cerebral ischemia were found with the lithium salt of 2-acetoxybenzoylglycylglycine.

• 出版日期2018-4