Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults

作者：Sasayama Daimei^*; Hori Hiroaki; Teraishi Toshiya; Hattori Kotaro; Ota Miho; Matsuo Junko; Kawamoto Yumiko; Kinoshita Yukiko; Amano Naoji; Kunugi Hiroshi

来源：Journal of Neural Transmission, 2012, 119(3): 313-318.

DOI：10.1007/s00702-011-0709-3

• Cognitive function
• Interleukin-6
• Genetic polymorphism
• Intelligence

Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory.

• 出版日期2012-3