A(2A) adenosine receptors and Parkinson%26apos;s disease severity

作者：Casetta I^*; Vincenzi F; Bencivelli D; Corciulo C; Gentile M; Granieri E; Borea P A; Varani K

来源：Acta Neurologica Scandinavica, 2014, 129(4): 276-281.

DOI：10.1111/ane.12181

• motor complications
• Parkinson%26apos
• s disease
• disease progression
• A2A adenosine receptor

Objectives %26lt;br%26gt;In the last decade, increasing evidence suggests a key role of adenosine in Parkinson%26apos;s disease (PD) and A(2A) adenosine receptors (A(2A)ARs) as an important pharmacological target in PD. An overexpression of A(2A)ARs has been found in putamen and in peripheral blood cells of PD patients. The primary aim of this study was to verify whether the alterations in A(2A)ARs in lymphocytes of PD subjects correlate with disease severity. %26lt;br%26gt;Material and methods %26lt;br%26gt;A consecutive sample of PD patients was enrolled. A clinical examination and a face-to-face interview were carried out. A(2A)ARs were investigated to verify the affinity and receptor density in lymphocyte membranes. The data were compared with those found in healthy controls. Moreover, the correlation between A(2A)AR density and affinity and clinical variables was evaluated in PD patients. %26lt;br%26gt;Results %26lt;br%26gt;In human lymphocyte membranes from PD patients, an increase in A(2A)AR density and a decrease in A(2A)AR affinity were found if compared with healthy subjects. A statistically significant correlation between the A(2A)AR density or affinity and specific clinical parameters as motor and cognitive impairment was detected. Patients with higher A(2A)AR density and lower affinity were more likely to exhibit motor complications. %26lt;br%26gt;Conclusions %26lt;br%26gt;Parkinson%26apos;s disease patients show an A(2A)AR upregulation in lymphocyte membranes if compared with healthy subjects. The correlation found between A(2A)AR density or affinity and clinical parameters highlights the central role of A(2A)AR modulation in the pharmacological treatment for PD and could suggest the putative role of A(2A)AR as a candidate biomarker of PD severity.

• 出版日期2014-4