Embedding a Cardiac Pulsatile Model Into an Integrated Model of the Cardiovascular Regulation for Heart Failure Followup

作者：Le Rolle Virginie^*; Ojeda David; Hernandez Alfredo I

来源：IEEE Transactions on Biomedical Engineering, 2011, 58(10): 2982-2986.

DOI：10.1109/TBME.2011.2159715

• Cardiac resynchronization therapy
• Computational modeling
• heart failure

The analysis of followup data from patients suffering from heart failure is a difficult task, due to the complex and multifactorial nature of this pathology. In this paper, we present a coupled model, integrating a pulsatile heart into a model of the short to long-term regulations of the cardiovascular system. An interface method is proposed to couple these models, which present significantly different time scales. Results from a sensitivity analysis of the original and integrated models are proposed with simulations reproducing the main effects of the short- and long-term responses of an acute decompensated heart failure episode on a patient undergoing cardiac resynchronization therapy.

• 出版日期2011-10