News from the End of the Gut-How the Highly Segmental Pattern of Colonic HCO3- Transport Relates to Absorptive Function and Mucosal Integrity

作者：Bachmann Oliver; Seidler Ursula^*

来源：Biological & Pharmaceutical Bulletin, 2011, 34(6): 794-802.

• large intestine
• salt absorption
• acid balance
• base balance
• permeability
• colitis

A number of transport mechanisms in the colonic epithelium contribute to HCO3- movement across the apical and basolateral membranes, but this ion has been largely regarded as a by-product of the transport functions it is involved in, such as NaCl- or short chain fatty acid (SCFA) absorption. However, emerging data points to several specific roles of HCO3- for colonic epithelial physiology, including pH control in the colonic surface microenvironment, which is important for transport- and immune functions, as well as the secretion and the rheological properties of the mucus gel. Furthermore, recent studies have demonstrated that colonic HCO3- transporters are expressed in a highly segmental as well as species-specific manner. This review summarizes recently gathered information on the functional anatomy of the colon, the roles of HCO3- in the colonic epithelium, colonic mucosal integrity, and the expression and function of HCO3- transporting mechanisms in health and disease.

• 出版日期2011-6