Antioxidant potential of Himanthalia elongata for protection against ischemia-reperfusion injury in the small bowel

作者：Belda Antoli Mariola^*; Padron Sanz Carolina; Cejalvo Lapena Dolores; Prieto Moure Beatriz; Miguel Lloris Cejalvo Jose; Miguel Lloris Carsi Jose

来源：Surgery, 2017, 162(3): 577-585.

DOI：10.1016/j.surg.2017.04.017

Background. Seaweed has been associated with the prevention and/or treatment of various diseases related to oxidative stress because of its antioxidant activity. We investigated the protective potential of extract of Himanthalia elongata against ischemia-reperfusion (I/R) injury in the intestine of rats.
Methods. Seventy-two (72) male Wistar albino rats were randomly assigned into 12 groups as follows: sham, I/R only, I/R plus vehicle at 3 time points, and I/R plus extract at 3 time points. The degree of intestinal injury was determined by oxidative stress using lipid peroxidation, superoxide dismutase, catalase, and glutathione peroxidase after mesenteric ischemia-reperfusion. A histological study was also performed.
Results. The algae extract helps to maintain normal enzymatic levels because, for all the studied parameters, groups treated with the extract showed significant differences (P < .05) compared with the I/R groups, and there were no differences compared with the sham group. The histological study showed that damage to the intestinal mucosa was less severe in animals treated with extract of H elongata after up to 24 hours of reperfusion compared with the I/R group.
Conclusion. These results suggest that the extract of H elongata can protect intestinal tissue against ischemia-reperfusion injury.

• 出版日期2017-9