Normoalbuminuric kidney impairment in patients with T1DM: insights from annals initiative

作者：Lamacchia Olga; Viazzi Francesca; Fioretto Paola; Mirijello Antonio; Giorda Carlo; Ceriello Antonio; Russo Giuseppina; Guida Pietro; Pontremoli Roberto; De Cosmo Salvatore^*

来源：Diabetology & Metabolic Syndrome, 2018, 10(1): 60.

DOI：10.1186/s13098-018-0361-2

• Albuminuria
• Chronic kidney disease
• Type 1 diabetes mellitus
• Cardiovascular disease

Background: We described, in a large sample of patients with type 1 diabetes mellitus (T1DM) and GFR < 60 mL/min/1.73 m(2) (with or without albuminuria), the differences in the clinical features associated with the two different chronic kidney disease phenotypes and we investigated, in a subset of patients, the modulating role of albuminuria on kidney disease progression.
Methods: Clinical data of 1395 patients with T1DM were extracted from electronic medical records.
Results: Albuminuria was detected in 676 (48.5%) patients, with the remaining 719 (51.5%) patients having normoalbuminuric renal impairment. Those with albuminuria showed an evident worse cardiovascular risk profile as compared to patients with normoalbuminuria. A subgroup of 582 patients was followed up over a 4-year period. One hundred and twenty five patients (21.5%) showed a loss of eGFR > 30%. The proportion of patients reaching the renal outcome was significantly higher among those with baseline albuminuria as compared to patients with normoalbuminuria (P <0.0001). At the multivariate logistic analysis microalbuminuria, macroalbuminuria and proliferative retinopathy were the only parameters independently associated to eGFR reduction.
Conclusions: The proportion of T1DM patients with normoalbuminuria renal impairment is high (about 50%). These patients have a slower eGFR decline as compared to that observed in patients with albuminuria renal impairment.

• 出版日期2018-7-31