A near-infrared BSA coated DNA-AgNCs for cellular imaging

作者：Mu, Wei-Yu; Yang, Rui; Robertson, Akrofi; Chen, Qiu-Yun^*

来源：Colloids and Surfaces B: Biointerfaces , 2018, 162: 427-431.

DOI：10.1016/j.colsurfb.2017.12.023

• DNA-AgNCs
• Stability
• Cellular imaging
• BSA

Near-infrared silver nanoclusters, have potential applications in the field of biosensing and biological imaging. However, less stability of most DNA-AgNCs limits their application. To obtain stable near-infrared fluorescence DNA-AgNCs for biological imaging, a new kind of near-infrared fluorescent DNA-Ag nanoclusters was constructed using the C3A rich aptamer as a synthesis template, GAG as the enhancer. In particular, a new DNA-AgNCs-Trp@BSA was obtained based on the self-assembly of bovine serum albumin (BSA) and tryptophan loaded DNA-AgNCs by hydrophobic interaction. This self-assembly method can be used to stabilize DNAn-Ag (n=1-3) nanoclusters. Hence, the near-infrared fluorescence DNA-AgNCs-Trp@BSA was applied in cellular imaging of HepG-2 cells.

• 出版日期2018-2-1
• 单位江苏大学