An efficient synthesis of LipidGreen and its derivatives via microwave assisted reaction and their live lipid imaging in zebrafish

作者：Pagire Haushabhau S; Chun Hang Suk; Bae Myung Ae^*; Ahn Jin Hee

来源：Tetrahedron, 2013, 69(14): 3039-3044.

DOI：10.1016/j.tet.2013.01.090

• LipidGreen
• Fluorescent probe
• Lipid imaging
• Small molecule
• Zebrafish

We have developed an efficient synthesis of LipidGreen. The conversion is achieved by selective methylation with trimethylsilyldiazomethane, selective deprotection by BBr3 and an improved microwave-assisted C-allylation procedure. Using this route, we have synthesized novel LipidGreen derivatives, and evaluated their live imaging abilities in zebrafish. In this series, Compound 7 is the most active, which is at least 10 fold more potent than LipidGreen.

• 出版日期2013-4-8